Overview

I am a computational and statistical investigator at Brigham and Women’s Hospital affiliated with Harvard Medical School with focuses on biomedical data, particularly neuroscience, genetics, oncology, and cardiovascular research. My work spans the full spectrum of biomedical/clinical investigation, including:

• a) Biobank Studies: Large-scale imaging/digital-device/omics research using biobanks and population cohorts (e.g., Human Connectome Project, ABCD Study, Boston Scientific’s ALTITUDE database, and NCDR ICD Registry) for biomarker discovery and disease stratification using AI/ML-based data science and digital health approaches.;
• c) Epidemiological Real-world Studies and Outcomes Research: Analysis of EHRs, insurance claims, registry data (e.g., National Inpatient Sample) for treatment effectiveness, safety evaluation, and patient trajectory modeling using advanced causal inference and survival methods.
• b) Clinical Trials: Supporting clinical studies, including Phase IV Design, trial endpoint evaluation using rigorous statistical methodology.;

I have participated in a number of studies as a leading biostatistics investigator and a statistics collaborator. As a leading investigator, I have served as a lead author on more than 15 publications in leading journals such as Imaging Neuroscience, NeuroImage: Clinical, Bioinformatics, Data Science in Science, and JAMIA Open with open codes and software available at https://github.com/lanzhouBWH.As a statistics collaborator, I have co-authored over 50 collaborative papers in high-impact biomedical and clinical journals, including The New England Journal of Medicine, Journal of the American Heart Association, Circulation, Human Brain Mapping, Neuro-Oncology, and Radiology. Currently, my work is expanding to incorporate artificial intelligence.